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题目:: Identification of B cells in multilineage hematopoietic colonies derived from cells of patients with lymphocytic lymphoma.
作者:: Fauser(A A),Kanz(L),Löhr(G W)
状态:: 发布时间1985-03-27 , 更新时间 2013-09-29
期刊:: Proc Natl Acad Sci U S A
摘要:: Pluripotent stem cells from human bone marrow can be identified in culture by their ability to form multilineage hematopoietic colonies containing different myeloid lineages and T cells of different phenotypes. The observation of a common progenitor of myeloid and lymphoid cells in normal and disturbed hematopoiesis prompted the question of whether B cells are part of the differentiation program of stem cells. The availability of hybridomas of azaguanine-resistant T-cell lines secreting monoclonal growth factors for B cells and clinical conditions that are considered to originate from malignant B cells might facilitate this investigation. We were able to identify surface immunoglobulin and B-cell-associated antigen-positive cells within such colonies, indicating that B cells are generated from a myelolymphopoietic stem cell. This report describes the presence of B cells in these colonies derived from bone marrow cells of patients with non-Hodgkin lymphoma.
语言:: eng
DOI:

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