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PMID: 3874730 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Dynamics of T cells of L3T4 and Ly 2 phenotype within granulomas in murine listeriosis.

Clinical and experimental immunology ·Vol. 60 ·No. 3 ·1985-06-00 ·Pages 559-64

Näher H, Sperling U, Takacs L, Hahn H

Abstract

Monoclonal antibodies anti-Ly 1, anti-Ly 2 and GK1.5 were applied to determine phenotypes of T cells within granulomas formed as a result of infection of mice with the facultative intracellular bacterium Listeria monocytogenes. Early in granuloma formation, equal numbers of Ly 1+, Ly 2+ and L3T4+ cells were found, T cells of different phenotypes being evenly distributed over the lesions. In mature granulomas, numbers of Ly 1+ and L3T4+ cells about doubled as compared to incipient granulomas, Ly 2+ cells, however, remained constant. Whereas Ly 1+ and L3T4+ cells within mature granulomas still were evenly distributed, Ly 2+ cells were predominantly localized in the periphery of the lesions. The data indicate that both, specific Ly 2+ and L3T4+ T cells, display characteristic dynamics within granulomas: Ly 2+ T cells which most likely mature from Ly 1+2+ T cells over time locate to the periphery. Concomitantly, L3T4+ T cells are enriched maintaining their distribution all over the lesions.

MeSH Terms

Animals Antibodies, Monoclonal/immunology Granuloma/immunology,pathology Immunization, Passive Leukocyte Count Listeriosis/immunology,pathology Liver/pathology Mice Mice, Inbred C57BL Phenotype T-Lymphocytes/classification,immunology

Chemicals

Antibodies, Monoclonal

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Näher H

Sperling U

Takacs L

Hahn H

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21 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1985-06-00

Pages

559-64

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1577196

Subset

External Links

PubMed source PMC Full Text View journal details

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Dynamics of T cells of L3T4 and Ly 2 phenotype within granulomas in murine listeriosis.

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