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PMID: 3863142 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Differentiating effects of murine nerve growth factor in the peripheral and central nervous systems of Xenopus laevis tadpoles.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 20 ·1985-10-00 ·Pages 7111-5

Levi-Montalcini R, Aloe L

Abstract

The present investigation was directed toward exploration of the spectrum of action of murine nerve growth factor (m-NGF) in peripheral cells and neurons in the central nervous system (CNS) of Xenopus laevis tadpoles. It was found that systemic m-NGF injections elicit growth and differentiative effects not only on sensory and sympathetic nerve cells but also on several populations in the CNS. The finding that aminergic and peptidergic neurons in brain centers are highly receptive to m-NGF activity provides evidence for the broad spectrum of action of this molecule in lower vertebrates and calls for a systematic search for these and other putative target cells in the CNS of higher vertebrates.

MeSH Terms
Aging Animals Cell Differentiation/drug effects Central Nervous System/growth & development Female Immunoglobulin G Larva Male Mice Nerve Growth Factors/pharmacology Neurons/cytology,drug effects Peripheral Nerves/growth & development Xenopus
Chemicals
Immunoglobulin G Nerve Growth Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Levi-Montalcini R
Aloe L
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20 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.82.20.7111
Published
1985-10-00
Pages
7111-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC391320
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.82.20.7111 PMC Full Text View journal details
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