Influence of dendritic cells on tumor growth.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 13 ·1985-07-00 ·Pages 4495-7

Knight SC, Hunt R, Dore C, Medawar PB

Abstract

Dendritic cells (DC) exposed to antigen are potent initiators of immune responses, and the numbers of DC and the dose of antigen control the level of response. The influence of these variables was tested on the growth of mouse sarcoma cells in vivo. When normal syngeneic DC (100,000) were given to mice with palpable tumors, tumor regression or delay in tumor growth was obtained. DC exposed to increasing doses of tumor extract in vitro before administration had progressively less effect. DC exposed to antigen delayed tumor growth significantly only when given on the same day as 500 tumor cells. The studies suggested that low doses of antigen on DC elicit immune responses and that high doses block them. The numbers of antigen-presenting cells and the dose of antigen modulate the degree of immunity to mouse sarcoma in vivo.

MeSH Terms

Animals Antibody Formation Antigen-Presenting Cells/immunology Cell Division Dendrites/immunology Mice Sarcoma, Experimental/immunology Spleen/cytology

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Knight S C

Hunt R

Dore C

Medawar P B

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13 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.82.13.4495

Published

1985-07-00

Pages

4495-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC391128

Subset

External Links

PubMed source DOI: 10.1073/pnas.82.13.4495 PMC Full Text View journal details

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