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PMID: 3857214 Published · ppublish English Journal Article

Forty four probands with an additional "marker" chromosome.

Human genetics ·Vol. 69 ·No. 4 ·1985-00-00 ·Pages 353-70

Buckton KE, Spowart G, Newton MS, Evans HJ

Abstract

Information is presented which has been obtained from an exhaustive examination of 44 probands with a supernumerary marker chromosome (mar) and their families. The data include the derivation of the mar, frequency in various populations, inheritance and possible effect on fertility, congenital abnormality, and mental ability. The practical problems in assessing the risk of abnormality in a foetus discovered during prenatal diagnosis to be carrying a mar, are discussed.

MeSH Terms
Adult Aged Chromosome Banding Chromosomes, Human, 13-15 Chromosomes, Human, 21-22 and Y Female Genetic Markers Humans Infant, Newborn Infertility/genetics Intellectual Disability/genetics Karyotyping Male Maternal Age Middle Aged Mosaicism Paternal Age Pedigree Pregnancy Trisomy Twins
Chemicals
Genetic Markers
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Buckton K E
Spowart G
Newton M S
Evans H J
References (47)
47 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00291656
Published
1985-00-00
Pages
353-70
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00291656 View journal details
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