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PMID: 384969 Published · ppublish English Journal Article Review

The carcinogenicity of lead.

Archives of toxicology ·Vol. 42 ·No. 2 ·1979-06-08 ·Pages 87-94

Moore MR, Meredith PA

Abstract

The potential for lead to cause neoplasm in animals and man is reviewed. A multitude of studies indicate that principally renal tumours may be produced by various forms of inorganic lead in small rodents. No human study either of an epidemiological form or of a case report in industrial, agricultural or community medicine has proven that lead may cause cancer in man.

MeSH Terms
Animals Carcinogens Humans Kidney/drug effects Lead/metabolism,toxicity Occupational Diseases/chemically induced,epidemiology United States
Chemicals
Carcinogens Lead
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Moore M R
Meredith P A
References (52)
52 references, click to expand
  1. Chronic nephritis in Queensland.
    Australas Ann Med. 1955 Aug;4(3):163-77 PMID: 13269335
  2. Nephropathy in chronic lead poisoning.
    Arch Intern Med. 1966 Jul;118(1):17-29 PMID: 5940188
  3. Acute lead poisoning: Five cases resulting from self-injection of lead and opium.
    Q J Med. 1975 Apr;44(174):275-84 PMID: 1178812
  4. [Renal adenoma and carcinoma produced by lead poisoning in rats, and relations to corresponding neoplastic formations in man].
    Virchows Arch Pathol Anat Physiol Klin Med. 1953;323(6):694-710 PMID: 13102931
  5. [Leaded gasoline and cancer mortality].
    Schweiz Med Wochenschr. 1976 Apr 10;106(15):503-6 PMID: 824726
  6. Cancer mortality patterns in the lead industry.
    Ann N Y Acad Sci. 1976;271:250-9 PMID: 1069512
  7. A comparison of concentrations of lead in human tissues.
    Br J Ind Med. 1975 May;32(2):119-39 PMID: 1131339
  8. A survey of metal carcinogenesis.
    Prog Exp Tumor Res. 1969;12:102-33 PMID: 4905208
  9. HEALTH CONTROL IN INORGANIC LEAD INDUSTRIES. A FOLLOW-UP OF EXPOSED WORKERS.
    Arch Environ Health. 1964 Feb;8:243-50 PMID: 14089338
  10. Lung cancer in uranium miners and long-term exposure to radon daughter products.
    Health Phys. 1976 Jun;30(6):433-7 PMID: 955899
  11. Effects of lead oxide on the induction of lung tumors in Syrian hamsters.
    J Natl Cancer Inst. 1974 May;52(5):1605-10 PMID: 4831445
  12. CHRONIC LEAD NEPHROPATHY: THE DIAGNOSTIC USE OF CALCIUM EDTA AND THE ASSOCIATION WITH GOUT.
    Australas Ann Med. 1963 Nov;12:310-24 PMID: 14078907
  13. [Correlation between neoplasm mortality and the metal ion content of urban drinking water].
    Minerva Med. 1970 May 5;61(36):1941-50 PMID: 5422052
  14. The induction of renal tumours by feeding of basic lead acetate to rats.
    Br J Cancer. 1962 Jun;16:289-97 PMID: 13890724
  15. Lung cancer induced in hamsters by low doses of alpha radiation from polonium-210.
    Science. 1975 May 16;188(4189):737-8 PMID: 1124396
  16. The induction of renal tumours by feeding basic lead acetate to mice and hamsters.
    Br J Cancer. 1969 Dec;23(4):765-71 PMID: 5367336
  17. Environmental metallic carcinogens: an overview of exposure levels.
    J Toxicol Environ Health. 1976 Sep;2(1):77-109 PMID: 792462
  18. Aminoaciduria as a manifestation of renal tubular injury in lead intoxication and a comparison with patterns of aminoaciduria seen in other diseases.
    J Pediatr. 1962 Jan;60:1-17 PMID: 13879030
  19. Activation of the Rauscher leukemia virus by metals.
    J Natl Cancer Inst. 1973 Aug;51(2):609-13 PMID: 4797261
  20. [Kidney changes in experimental chronic lead poisoning in rats].
    Z Gesamte Exp Med. 1957;128(4):361-77 PMID: 13456682
  21. Uneven distribution of cancer in West Devon, with particular reference to the divers water-supplies.
    Lancet. 1960 Jun 4;1(7136):1235-8 PMID: 13792792
  22. Lead concentration in human brain tissue: an autopsy study.
    Arch Environ Health. 1973 Dec;27(6):383-6 PMID: 4752701
  23. The induction of renal tumors by feeding lead acetate to rats.
    Br J Cancer. 1962 Jun;16:283-8 PMID: 13872194
  24. Etiologic factors in lead nephropathy.
    South Med J. 1976 Nov;69(11):1445-9 PMID: 1019639
  25. Occurrence of trace metals in the environment: an overview.
    Am Ind Hyg Assoc J. 1973 May;34(5):217-26 PMID: 4729287
  26. The effects of industrial lead poisoning on cytochrome P450 mediated phenazone (antipyrine) hydroxylation.
    Eur J Clin Pharmacol. 1977 Nov 14;12(3):235-9 PMID: 412677
  27. [Experimental studies of organic lead preparation (SPA) action on the growth of Brown-Pearce carcinoma implanted in the iris and conjunctiva of the eye globe].
    Oftalmol Zh. 1977;32(1):45-9 PMID: 559993
  28. Radioactivity of tobacco trichomes and insoluble cigarette smoke particles.
    Nature. 1974 May 17;249(454):215-7 PMID: 4833238
  29. Drug metabolism in normal children, lead-poisoned children, and normal adults.
    Clin Pharmacol Ther. 1975 Feb;17(2):179-83 PMID: 804369
  30. Cadmium, zinc, copper, and lead in human renal cortex.
    Arch Environ Health. 1972 Jun;24(6):426-31 PMID: 5031567
  31. Study on the carcinogenicity of lead arsenate and sodium arsenate and on the possible synergistic effect of diethylnitrosamine.
    Food Cosmet Toxicol. 1974 Oct;12(5-6):671-9 PMID: 4452539
  32. Correlations between carcinogenic trace metals in water supplies and cancer mortality.
    Ann N Y Acad Sci. 1972 Jun 28;199:249-64 PMID: 4506509
  33. Life term studies on the effect of trace elements on spontaneous tumors in mice and rats.
    Cancer Res. 1969 Apr;29(4):892-5 PMID: 5777793
  34. [Tricidence of leukoplakia in certain occupational groups].
    Czas Stomatol. 1968 Aug;21(8):909-12 PMID: 5245396
  35. Lead dosage and the role of the intranuclear inclusion body. An experimental study.
    Arch Environ Health. 1970 Jun;20(6):705-11 PMID: 5443344
  36. Cerebral tumour in a lead worker.
    Br J Ind Med. 1961 Apr;18:153-6 PMID: 13737259
  37. The renal tubule in lead poisoning. I. mMitochondrial swelling and aminoacidura.
    Lab Invest. 1968 Jul;19(1):71-7 PMID: 5671355
  38. Lead in human tissues.
    Toxicol Appl Pharmacol. 1975 Jun;32(3):638-51 PMID: 1154419
  39. A FOLLOW-UP STUDY OF LEAD WORKERS.
    Br J Ind Med. 1963 Oct;20:313-5 PMID: 14072623
  40. Mortality of lead workers.
    J Occup Med. 1975 Feb;17(2):100-7 PMID: 1142019
  41. The fine structure and histochemistry of lean-induced renal tumors in rats.
    Am J Pathol. 1967 Apr;50(4):571-603 PMID: 4225664
  42. Cancer mortality correlation studies--IV: associations with dietary intakes and blood levels of certain trace elements, notably Se-antagonists.
    Bioinorg Chem. 1977;7(1):35-56 PMID: 856292
  43. Failure of testosterone or xanthopterin to influence the induction of renal neoplasms by lead in rats.
    Br J Cancer. 1965 Dec;19(4):860-6 PMID: 5862663
  44. Hepatic drug metabolism and haem biosynthesis in lead-poisoned rats.
    Br J Pharmacol. 1978 Apr;62(4):529-36 PMID: 656697
  45. Prevention of long-term sequelae following the absorption of lead.
    Arch Environ Health. 1971 Oct;23(4):292-8 PMID: 5111312
  46. [Effect of toxic environmental products on the formation of leukoplakia in workers of zinc and lead processing plants].
    Czas Stomatol. 1975 Jan;28(1):103-10 PMID: 1053700
  47. Trace elements in plants and soil in relation to cancer.
    S Afr Med J. 1974 Nov 23;48(57):2363-4 PMID: 4473839
  48. Mortality among orchard workers exposed to lead arsenate spray: a cohort study.
    J Chronic Dis. 1973 Feb;26(2):105-18 PMID: 4694190
  49. [Topochemical behaviour of tubular enzyme pattern in experimental cancerization (author's transl)].
    Exp Pathol (Jena). 1973;8(2):137-54 PMID: 4777264
  50. Chemical carcinogenesis.
    Annu Rev Biochem. 1975;44:79-121 PMID: 1094923
  51. Induction of cerebral gliomas in rats with dietary lead subacetate and 2-acetylaminofluorene.
    Cancer Res. 1970 May;30(5):1248-61 PMID: 5426930
  52. [Tumors and disorders of porphyrin metabolism in rats with chronic experimental lead poisoning. I. Morphological studies].
    Zentralbl Allg Pathol. 1968;111(1):1-12 PMID: 4906497
Article Info
Journal
Archives of toxicology
Abbr.
Arch Toxicol
ISSN
0340-5761
DOI
10.1007/BF00316488
Published
1979-06-08
Pages
87-94
Language
English
Region
Germany
NLM ID
0417615
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00316488 View journal details
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