Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs.

Nature ·Vol. 316 ·No. 6024 ·1985-00-00 ·Pages 126-31

Richardson BP, Engel G, Donatsch P, Stadler PA

Abstract

We describe a new class of drugs that selectively block serotonin M-receptors on peripheral neurones. Because of their high affinity, some of these drugs are the most potent of any pharmacological class yet reported. They have allowed the identification of three M-receptor subtypes, one of which is responsible for mediating the painful effects of serotonin in humans.

MeSH Terms

Animals Bradykinin/pharmacology Cerebral Cortex Female Guinea Pigs Heart/innervation Humans Ileum Indoles/metabolism,pharmacology Male Muscle, Smooth/innervation Neurons/metabolism Pain/chemically induced Peripheral Nerves/metabolism Rabbits Rats Receptors, Serotonin/metabolism,physiology Serotonin/analogs & derivatives,metabolism,pharmacology Tropisetron Vagus Nerve

Chemicals

Indoles Receptors, Serotonin alpha-methylserotonin Serotonin Tropisetron 2-methyl-5-HT Bradykinin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Richardson B P

Engel G

Donatsch P

Stadler P A

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/316126a0

Published

1985-00-00

Pages

126-31

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/316126a0 View journal details

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Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs.

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