Partial characterization of a malaria mitogen.

Transactions of the Royal Society of Tropical Medicine and Hygiene ·Vol. 73 ·No. 2 ·1979-00-00 ·Pages 178-82

Greenwood BM, Oduloju AJ, Platts-Mills TA

Abstract

Supernatants from 24-hour cultures of Plasmodium falciparum-infected human red blood cells stimulated lymphocytes from both malaria immune and malaria non-immune donors. Both T and B lymphocytes responded. Amalaria parasite-derived mitogen may play some part in the pathogenesis of the hypergammaglobulinaemia characteristic of malaria.

MeSH Terms

Child Child, Preschool Erythrocytes/immunology Humans Hypergammaglobulinemia/etiology Immunoglobulin M/biosynthesis Infant Interleukin-2/analysis,pharmacology Lymphocytes/metabolism Lymphokines/analysis Malaria/complications,immunology Phytohemagglutinins/pharmacology Plasmodium falciparum

Chemicals

Immunoglobulin M Interleukin-2 Lymphokines Phytohemagglutinins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Greenwood B M

Oduloju A J

Platts-Mills T A

Article Info

Journal

Transactions of the Royal Society of Tropical Medicine and Hygiene

Abbr.

Trans R Soc Trop Med Hyg

ISSN

0035-9203

DOI

10.1016/0035-9203(79)90204-9

Published

1979-00-00

Pages

178-82

Language

English

Region

England

NLM ID

7506129

Subset

External Links

PubMed source DOI: 10.1016/0035-9203(79)90204-9 View journal details

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Partial characterization of a malaria mitogen.

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