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PMID: 38131 Published · ppublish English Journal Article

Action of putative neurotransmitters in the guinea pig cochlea.

Experimental brain research ·Vol. 36 ·No. 1 ·1979-06-01 ·Pages 119-28

Comis SD, Leng G

Abstract

Scala tympani of the guinea pig was perfused with artificial perilymph containing putative transmitter substances. Single auditory nerve fibre activity was recorded during these perfusions and the responses of these fibres were studied using computer-controlled routine. Acetylcholine significantly inhibited tone-induced responses of a large proportion of the fibres tested. Glutamate appeared to be a potent depolarising agent when applied in concentrations between 2 and 10 mM. Noradrenaline did not affect tone-induced activity, but inhibited the spontaneous activity of some fibres. The results support the view that acetylcholine is the transmitter at synapses of the olivocochlear bundle, and that glutamate may be involved in the afferent synapse. The data do not support the hypothesis that noradrenaline is the afferent transmitter.

MeSH Terms
Acetylcholine/pharmacology Acoustic Stimulation Animals Aspartic Acid/pharmacology Auditory Pathways/drug effects Cochlea/drug effects Evoked Potentials/drug effects Glutamates/pharmacology Guinea Pigs Nerve Fibers/drug effects Neurotransmitter Agents/pharmacology Norepinephrine/pharmacology Olivary Nucleus/drug effects Vestibulocochlear Nerve/drug effects
Chemicals
Glutamates Neurotransmitter Agents Aspartic Acid Acetylcholine Norepinephrine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Comis S D
Leng G
References (23)
23 references, click to expand
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Article Info
Journal
Experimental brain research
Abbr.
Exp Brain Res
ISSN
0014-4819
DOI
10.1007/BF00238472
Published
1979-06-01
Pages
119-28
Language
English
Region
Germany
NLM ID
0043312
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00238472 View journal details
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