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PMID: 3807638 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a block copolymer--poloxamine 908.

Life sciences ·Vol. 40 ·No. 4 ·1987-01-26 ·Pages 367-74

Illum L, Davis SS, Müller RH, Mak E, West P

Abstract

Colloidal carriers injected intravenously are normally removed rapidly and efficiently by the liver and this represents a major barrier to drug targeting. By coating model microspheres and emulsions with a block co-polymer (poloxamine) it has been possible to keep the carrier circulating in the vascular compartment with little or no uptake by the reticuloendothelial system.

MeSH Terms

Animals Colloids Ethylenediamines Kidney/metabolism Liver/metabolism Lung/metabolism Microspheres Myocardium/metabolism Poloxalene/metabolism Polyethylene Glycols Polymers/metabolism Polystyrenes/metabolism Rabbits Spleen/metabolism

Chemicals

Colloids Ethylenediamines Polymers Polystyrenes tetronic 701 Polyethylene Glycols Poloxalene

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Illum L

Davis S S

Müller R H

Mak E

West P

Article Info

Journal

Life sciences

Abbr.

Life Sci

ISSN

0024-3205

DOI

10.1016/0024-3205(87)90138-x

Published

1987-01-26

Pages

367-74

Language

English

Region

Netherlands

NLM ID

0375521

Subset

External Links

PubMed source DOI: 10.1016/0024-3205(87)90138-x View journal details

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The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a block copolymer--poloxamine 908.

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