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PMID: 3754330 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Cloning of the gene coding for human L apoferritin.

Nucleic acids research ·Vol. 14 ·No. 7 ·1986-04-11 ·Pages 2863-76

Santoro C, Marone M, Ferrone M, Costanzo F, Colombo M, Minganti C, Cortese R, Silengo L

Abstract

A recently reported cDNA clone coding for human promyelocytic L apoferritin, shows some differences with a liver L apoferritin cDNA. We have investigated if these differences are due to the expression of different genes or to an alternative transcription of an unique gene. In this paper we report data suggesting that a single gene is mainly expressed in several tissues examined. This gene has been cloned and characterized. Its sequence shows three introns: the exon sequence is identical to that of cDNA clone isolated from human liver. A minimum of five related pseudogenes have been also analysed. One of them is a processed pseudogene interrupted by an intron-like fragment.

MeSH Terms

Amino Acid Sequence Apoferritins/genetics Base Sequence Cell Line Cloning, Molecular DNA/analysis Female Ferritins/analogs & derivatives Gene Expression Regulation HeLa Cells/analysis Humans Liver/analysis Microscopy, Electron Placenta/analysis Pregnancy

Chemicals

DNA Ferritins Apoferritins

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Santoro C

Marone M

Ferrone M

Costanzo F

Colombo M

Minganti C

Cortese R

Silengo L

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Article Info

Journal

Nucleic acids research

Abbr.

Nucleic Acids Res

ISSN

0305-1048

DOI

10.1093/nar/14.7.2863

Published

1986-04-11

Pages

2863-76

Language

English

Region

England

NLM ID

0411011

PMCID

PMC339708

Subset

Databases

GENBANK

X03742, X03743, X03744, X03745

External Links

PubMed source DOI: 10.1093/nar/14.7.2863 PMC Full Text View journal details

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Cloning of the gene coding for human L apoferritin.

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