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PMID: 3754016 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Monoclonal antibodies against the fusion protein are protective in necrotizing mumps meningoencephalitis.

Journal of virology ·Vol. 58 ·No. 1 ·1986-04-00 ·Pages 220-2

Löve A, Rydbeck R, Utter G, Orvell C, Kristensson K, Norrby E

Abstract

A monoclonal antibody against the fusion (F) protein of mumps virus was found to confer marked protection in mumps virus-induced encephalitis. Almost total prevention of extensive brain necrosis was found. This study indicates that the virus F protein is directly involved in the pathogenesis of brain necrosis.

MeSH Terms

Animals Animals, Newborn Antibodies, Monoclonal/immunology Brain/microbiology Cricetinae Meningoencephalitis/immunology,microbiology,prevention & control Mumps virus/immunology Viral Envelope Proteins/immunology Viral Fusion Proteins

Chemicals

Antibodies, Monoclonal Viral Envelope Proteins Viral Fusion Proteins

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Löve A

Rydbeck R

Utter G

Orvell C

Kristensson K

Norrby E

References (17)

17 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.58.1.220-222.1986

Published

1986-04-00

Pages

220-2

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC252897

Subset

External Links

PubMed source DOI: 10.1128/JVI.58.1.220-222.1986 PMC Full Text View journal details

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Monoclonal antibodies against the fusion protein are protective in necrotizing mumps meningoencephalitis.

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