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PMID: 3741770 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Dose-dependent localisation and potential for therapy of F(ab')2 fragments against CEA studied in a human tumour xenograft model.

British journal of cancer ·Vol. 54 ·No. 2 ·1986-08-00 ·Pages 341-4

Rogers GT, Harwood PJ, Pedley RB, Boden J, Bagshawe KD

Abstract

暂无摘要

MeSH Terms

Animals Carcinoembryonic Antigen/immunology Colonic Neoplasms/immunology,therapy Dose-Response Relationship, Immunologic Humans Immunoglobulin Fab Fragments/immunology Mice Mice, Nude Neoplasm Transplantation

Chemicals

Carcinoembryonic Antigen Immunoglobulin Fab Fragments

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Rogers G T

Harwood P J

Pedley R B

Boden J

Bagshawe K D

References (11)

11 references, click to expand

Tumor localization of radiolabeled antibodies against carcinoembryonic antigen in patients with carcinoma: a critical evaluation.
N Engl J Med. 1980 Jul 3;303(1):5-10 PMID: 7189578
Localization of mammary tumors in vivo with 131I-labeled Fab fragments of antibodies against mouse mammary epithelial (MME) antigens.
Cancer. 1981 Oct 15;48(8):1768-75 PMID: 7284975
Preparation of F(ab')2 fragments from mouse IgG of various subclasses.
J Immunol Methods. 1983 Jan 28;56(2):235-43 PMID: 6402547
Improved radioimaging and tumor localization with monoclonal F(ab')2.
J Nucl Med. 1983 Apr;24(4):316-25 PMID: 6339689
Radiolabeled fragments of monoclonal antibodies against carcinoembryonic antigen for localization of human colon carcinoma grafted into nude mice.
J Exp Med. 1983 Aug 1;158(2):413-27 PMID: 6886623
Dose dependent localisation of a monoclonal F(ab')2 fragment against CEA in the mouse xenograft model.
Eur J Cancer Clin Oncol. 1986 Jun;22(6):709-10 PMID: 3743606
Radioimmunodetection and radioimmunotherapy.
Cancer Invest. 1984;2(5):363-81 PMID: 6388741
Recent advances in tumour imaging. Use of radiolabelled antitumour antibodies.
Biochim Biophys Acta. 1985;780(2):151-66 PMID: 2988609
Comparative tumour localization of antibody fragments and intact IgG in nude mice bearing a CEA-producing human colon tumour xenograft.
Eur J Cancer Clin Oncol. 1985 Dec;21(12):1515-22 PMID: 3830730
Dynamics of monoclonal antibody distribution and prolonged tumour localisation in nude mice bearing a human CEA-producing colon carcinoma xenograft.
Tumour Biol. 1986;6(5):453-63 PMID: 3704478
Tumor immunotherapy in the mouse with the use of 131I-labeled monoclonal antibodies.
J Natl Cancer Inst. 1984 Mar;72(3):697-704 PMID: 6583453

Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/bjc.1986.183

Published

1986-08-00

Pages

341-4

Language

English

Region

England

NLM ID

0370635

PMCID

PMC2001517

Subset

External Links

PubMed source DOI: 10.1038/bjc.1986.183 PMC Full Text View journal details

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Dose-dependent localisation and potential for therapy of F(ab')2 fragments against CEA studied in a human tumour xenograft model.

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