Cell proliferation in the human mammary epithelium. Differential contribution by epithelial and myoepithelial cells.
The ductal system of the human breast consists of epithelial, myoepithelial, and basal clear cells. By labeling ducts and alveoli dissected from reduction mammoplasty specimens with 3H-thymidine in vitro and labeling human breast organoids xenografted in nude mice in vivo, it was found that cellular proliferation in the human breast is virtually confined to epithelial and basal clear cells. A pulse label of 3H-thymidine in organ culture explants was followed over a period of time, and it was found that myoepithelial cells originate from a precursor cell population within the mammary epithelium after a number of cell divisions. Myoepithelial cells were not seen to divide when fully mature.
18 references, click to expand
-
Cell proliferation in human melanoma.J Clin Invest. 1970 Jun;49(6):1188-99 PMID: 5422021
-
Ultrastructure of the human breast and its disorders.Am J Clin Pathol. 1976 Aug;66(2):291-375 PMID: 181979
-
The proliferative behavior of the human adult mammary epithelium.Acta Cytol. 1979 May-Jun;23(3):252-7 PMID: 294064
-
Basal clear cells of the normal human breast.Virchows Arch A Pathol Anat Histopathol. 1984;402(3):319-29 PMID: 6422622
-
[Morphology of the mammary gland in children].Frankf Z Pathol. 1958 Mar;69(1):36-52 PMID: 13538096
-
Observations on the ultrastructure of a mammary ductule.J Ultrastruct Res. 1967 Nov;21(1):9-25 PMID: 5583207
-
Morphological evaluation of cell turnover in relation to the menstrual cycle in the "resting" human breast.Br J Cancer. 1981 Aug;44(2):177-81 PMID: 7272186
-
Hormone-independent DNA synthesis by epithelial cells of adult human mammary gland in organ culture.Proc Soc Exp Biol Med. 1973 Jun;143(2):371-4 PMID: 4709004
-
A common source of difficulty in high-resolution radioautography.J Cell Biol. 1969 Jun;41(3):918-9 PMID: 5768881
-
Ultrastructure of the human mammary ductule.Cancer. 1969 Apr;23(4):958-78 PMID: 5775984
-
Cell proliferation in fibrocystic disease and postmenopause breast ducts measured by thymidine labeling.Cancer. 1982 Aug 15;50(4):746-51 PMID: 7093909
-
Cell turnover in the "resting" human breast: influence of parity, contraceptive pill, age and laterality.Br J Cancer. 1982 Sep;46(3):376-82 PMID: 7126427
-
Ultrastructure of the human mammary gland.Pathol Annu. 1971;6:1-59 PMID: 4342307
-
Role of the mitochondrion in the regulation of protein synthesis in the eucaryote Saccharomyces cerevisiae.Mol Gen Genet. 1971;110(2):110-7 PMID: 5550308
-
Preparation and identification of human breast epithelial cells in culture.Int J Cancer. 1980 Nov 15;26(5):577-84 PMID: 6263809
-
THE ORGANIZATION AND DUPLICATION OF CHROMOSOMES AS REVEALED BY AUTORADIOGRAPHIC STUDIES USING TRITIUM-LABELED THYMIDINEE.Proc Natl Acad Sci U S A. 1957 Jan 15;43(1):122-8 PMID: 16589984
-
Effect of hormone on human mammary duct in vitro.Horm Metab Res. 1978 Jul;10(4):337-40 PMID: 680631
-
The fine structure of the normal, resting terminal ductal-lobular unit of the female breast.Virchows Arch A Pathol Anat Histol. 1976 Dec 27;372(3):205-26 PMID: 827849
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