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题目:: Differential distribution of lymphocytes and accessory cells in mouse Peyer's patches.
作者:: Ermak(T H),Owen(R L)
状态:: 发布时间1986-08-13 , 更新时间 2015-11-19
期刊:: Anat Rec
摘要:: The aim of this immunohistologic study was to determine how lymphocytes and accessory cells associated with antigen processing are distributed in the domes of Peyer's patches. Monoclonal antibodies against mouse B cells (anti-B220), T cells (anti-Thy-1.2), T helper cells (anti-L3T4), T cytotoxic/suppressor cells (anti-Lyt-2), macrophages (anti-Mac-1), and Ia+ cells (anti-I-Ad) were applied to cryostat sections of mouse Peyer's patches and visualized with peroxidase-conjugated avidin-biotin complexes (ABC). The subepithelial dome, the dome epithelium, and the follicle crypt epithelium were ech surveyed for cells labeled with these antibodies. Each region had a characteristic and nonrandom distribution of labeled cells. In the subepithelial dome, B cells, T helper cells, macrophages, and Ia+ accessory cells formed a cellular meshwork between follicle and the dome epithelium. T cytotoxic/suppressor cells were sparse beneath the epithelium. In the dome epithelium, solitary and paired lymphocytes occurred both above and below the level of epithelial cell nuclei. B cells predominated, and both T helper cells and T cytotoxic/suppressor cells were present. B cells sometimes aggregated in small clusters. Macrophages were rarely observed in the epithelium. The distribution of cells in the dome epithelium was distinctly different from non-Peyer's patch intestine where T cytotoxic/suppressor cells predominated and B cells were few in number. Although lymphocytes were usually absent in crypts outside Peyer's patches, in follicle crypts B cells and T cells were seen but not Ia+ accessory cells or macrophages. Most of the T cells in the crypt epithelium were T cytotoxic/suppressor cells.(ABSTRACT TRUNCATED AT 250 WORDS)
语言:: eng
DOI:: 10.1002/ar.1092150208

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