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PMID: 3709526 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

The relation between the divergence of sequence and structure in proteins.

The EMBO journal ·Vol. 5 ·No. 4 ·1986-04-00 ·Pages 823-6

Chothia C, Lesk AM

Abstract

Homologous proteins have regions which retain the same general fold and regions where the folds differ. For pairs of distantly related proteins (residue identity approximately 20%), the regions with the same fold may comprise less than half of each molecule. The regions with the same general fold differ in structure by amounts that increase as the amino acid sequences diverge. The root mean square deviation in the positions of the main chain atoms, delta, is related to the fraction of mutated residues, H, by the expression: delta(A) = 0.40 e1.87H.

MeSH Terms

Amino Acid Sequence Animals Humans Mutation Protein Conformation Proteins/genetics Structure-Activity Relationship

Chemicals

Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Chothia C

Lesk A M

References (27)

27 references, click to expand

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Article Info

Journal

The EMBO journal

Abbr.

EMBO J

ISSN

0261-4189

Published

1986-04-00

Pages

823-6

Language

English

Region

England

NLM ID

8208664

PMCID

PMC1166865

Subset

Grants

NIGMS NIH HHS · GM25435 · United States

External Links

PubMed source PMC Full Text View journal details

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The relation between the divergence of sequence and structure in proteins.

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