Home LiteratureArticle Details

PMID: 3704650 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Non-Watson-Crick G.C and A.T base pairs in a DNA-antibiotic complex.

Science (New York, N.Y.) ·Vol. 232 ·No. 4755 ·1986-06-06 ·Pages 1255-8

Quigley GJ, Ughetto G, van der Marel GA, van Boom JH, Wang AH, Rich A

Abstract

The structure of a DNA octamer d(GCGTACGC) cocrystallized with the bisintercalator antibiotic triostin A has been solved. The DNA forms an unwound right-handed double helix. Four base pairs are of the Watson-Crick type while four are Hoogsteen base pairs, including two A.T and two G.C base pairs. This is the first observation in an oligonucleotide of Hoogsteen G.C base pairs where the cystosine is protonated. It is likely that these also occur in solutions of DNA complexed to this antibiotic.

MeSH Terms

Anti-Bacterial Agents/metabolism DNA/metabolism Models, Molecular Nucleic Acid Conformation Quinoxalines/metabolism

Chemicals

Anti-Bacterial Agents Quinoxalines triostin A DNA

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Quigley G J

Ughetto G

van der Marel G A

van Boom J H

Wang A H

Rich A

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.3704650

Published

1986-06-06

Pages

1255-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.3704650 View journal details

Analysis Services

Non-Watson-Crick G.C and A.T base pairs in a DNA-antibiotic complex.

Contact

WeChat Official Account