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PMID: 3664271 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Hyperalgesia to heat after intradermal injection of capsaicin.

Brain research ·Vol. 418 ·No. 1 ·1987-08-18 ·Pages 201-3

Simone DA, Ngeow JY, Putterman GJ, LaMotte RH

Abstract

Capsaicin injected intradermally into the human forearm lowered the pain threshold for heat at the injection site. Both the magnitude and duration of hyperalgesia were dose dependent over the range of 0.1-100 micrograms, given in a constant volume of 10 microliter. Thus, capsaicin may be a useful tool in studies of the neural mechanisms of hyperalgesia.

MeSH Terms

Analgesia Capsaicin/administration & dosage Dose-Response Relationship, Drug Hot Temperature Humans Injections, Intradermal Pain/physiopathology Sensory Thresholds Time Factors

Chemicals

Capsaicin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Simone D A

Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510.

Ngeow J Y

Putterman G J

LaMotte R H

Article Info

Journal

Brain research

Abbr.

Brain Res

ISSN

0006-8993

DOI

10.1016/0006-8993(87)90982-6

Published

1987-08-18

Pages

201-3

Language

English

Region

Netherlands

NLM ID

0045503

Subset

Grants

NEI NIH HHS · EY00237 · United States

NEI NIH HHS · EY05295 · United States

NINDS NIH HHS · NS14624 · United States

External Links

PubMed source DOI: 10.1016/0006-8993(87)90982-6 View journal details

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Hyperalgesia to heat after intradermal injection of capsaicin.

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