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PMID: 3663833 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Orientation of lipid tubules by a magnetic field.

Biophysical journal ·Vol. 52 ·No. 2 ·1987-08-00 ·Pages 295-301

Rosenblatt C, Yager P, Schoen PE

Abstract

Lipid tubules, which are straight hollow cylinders consisting of lipid bilayers, are shown to orient in strong magnetic fields. Birefringence measurements were made of dilute samples of tubules of 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine (DC23PC) in magnetic fields of up to 4 T. The tubules were found to orient with their long axes parallel to the field direction, with saturated orientation [P2 (cos theta] approximately greater than 0.95) found at approximately 2 T. From known distributions of lengths and the number of bilayers in the walls, a value delta chi = (-7 +/- 1) X 10(-9) erg cm-3 G-2 was calculated for the tubules, which compares well with some previously reported values for phosphatidylcholines. Magnetic alignment will permit more sophisticated structural studies of monomeric and polymeric tubules, and provide a method of orienting macromolecules in the tubule walls or interior.

MeSH Terms

Birefringence Diynes Lipid Bilayers Magnetics Mathematics Models, Biological Molecular Conformation Phosphatidylcholines

Chemicals

Diynes Lipid Bilayers Phosphatidylcholines 1,2-bis(10,12-tricosadiynoyl)phosphatidylcholine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Rosenblatt C

Francis Bitter National Magnet Laboratory, Massachusetts Institute of Technology, Cambridge 02139.

Yager P

Schoen P E

References (13)

13 references, click to expand

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Article Info

Journal

Biophysical journal

Abbr.

Biophys J

ISSN

0006-3495

DOI

10.1016/S0006-3495(87)83216-2

Published

1987-08-00

Pages

295-301

Language

English

Region

United States

NLM ID

0370626

PMCID

PMC1330080

Subset

External Links

PubMed source DOI: 10.1016/S0006-3495(87)83216-2 PMC Full Text View journal details

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Orientation of lipid tubules by a magnetic field.

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