Influence of lysozyme on aggregation of Staphylococcus aureus.

Journal of clinical microbiology ·Vol. 25 ·No. 9 ·1987-09-00 ·Pages 1587-90

Millar MR, Inglis T

Abstract

The conditions under which lysozyme aggregates Staphylococcus aureus were studied. Lysozyme was found to aggregate S. aureus at concentrations found in human tear secretions. Aggregate size depended upon lysozyme concentration, ionic strength, and bacterial concentration. There was a low level of adherence of S. aureus to corneal epithelial cells, and the adherence of a recent clinical isolate was not influenced by lysozyme concentrations found in human tear secretions. Lysozyme may enhance bacterial clearance from the corneal surface of the eye by promoting particle aggregation.

MeSH Terms

Bacterial Adhesion/drug effects Centrifugation, Density Gradient Cornea/microbiology Epithelium/microbiology Humans Muramidase/pharmacology Staphylococcus aureus/drug effects,metabolism Tears/enzymology

Chemicals

Muramidase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Millar M R

Department of Medical Microbiology, Old Medical School, University of Leeds, United Kingdom.

Inglis T

References (15)

15 references, click to expand

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Article Info

Journal

Journal of clinical microbiology

Abbr.

J Clin Microbiol

ISSN

0095-1137

DOI

10.1128/jcm.25.9.1587-1590.1987

Published

1987-09-00

Pages

1587-90

Language

English

Region

United States

NLM ID

7505564

PMCID

PMC269288

Subset

External Links

PubMed source DOI: 10.1128/jcm.25.9.1587-1590.1987 PMC Full Text View journal details

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Influence of lysozyme on aggregation of Staphylococcus aureus.

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