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PMID: 3620314 Published · ppublish English Journal Article

Alcohol, physical activity and other risk factors for colorectal cancer: a prospective study.

British journal of cancer ·Vol. 55 ·No. 6 ·1987-06-00 ·Pages 687-94

Wu AH, Paganini-Hill A, Ross RK, Henderson BE

Abstract

The aetiology of colorectal cancer was studied in a cohort of 11,888 residents of a retirement community. After four and one-half years of follow-up, 58 male and 68 female incident colorectal cancers were identified. Daily alcohol drinkers experienced nearly a two-fold increase in risk (2 sided P = 0.002). Colorectal cancer was also positively associated with Quetelet's index and inversely associated with avocational physical activity. The results were consistent for both sexes but were statistically significant only for males. With the exception of dietary vitamin C, none of the nutrients under study (i.e., vitamins A and E, dietary fibre, calcium, and beta carotene) showed a significant association with colorectal cancer. An inverse relationship between colorectal cancer and dietary vitamin C was observed in females, but there was no association with either vitamin C from supplements or with total vitamin C intake. Males and females who had 3 or more children showed a significantly reduced risk of colorectal cancer (RR = 0.45, 95% CI = 0.2, 0.9), but those with no children did not show the highest risk.

MeSH Terms
Age Factors Alcohol Drinking Colonic Neoplasms/etiology,pathology Diet Female Humans Male Physical Exertion Prospective Studies Rectal Neoplasms/etiology,pathology Reproduction Risk Smoking
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wu A H
Paganini-Hill A
Ross R K
Henderson B E
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/bjc.1987.140
Published
1987-06-00
Pages
687-94
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2002031
Subset
IM
External Links
PubMed source DOI: 10.1038/bjc.1987.140 PMC Full Text View journal details
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