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PMID: 361700 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Bacteriophage Mu-induced modification of DNA is dependent upon a host function.

Journal of bacteriology ·Vol. 136 ·No. 1 ·1978-10-00 ·Pages 423-8

Khatoon H, Bukhari AI

Abstract

The DNA of bacteriophage Mu, extracted from induced lysates, is partially resistant to digestion by the endonuclease BalI. This modification of DNA is controlled by the Mu modification function (mom), which acts in conjunction with the dam (DNA-adenine methylation) function of Escherichia coli. Since the BalI recognition site is apparently different from the dam recognition site, these results imply that either the specificity of the dam function is changed by the mom function or the mom function requires the dam function for its activity.

MeSH Terms

Coliphages/genetics,metabolism DNA Restriction Enzymes DNA, Viral/metabolism Escherichia coli/genetics,metabolism Genes Methylation Mutation

Chemicals

DNA, Viral DNA Restriction Enzymes

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Khatoon H

Bukhari A I

References (7)

7 references, click to expand

Complementary specificity of restriction endonucleases of Diplococcus pneumoniae with respect to DNA methylation.
J Mol Biol. 1977 Jul;114(1):153-68 PMID: 20509
DNA modification of bacteriophage Mu-1 requires both host and bacteriophage functions.
J Virol. 1977 Sep;23(3):825-6 PMID: 330882
A specific endonuclease from Brevibacterium albidum.
J Mol Biol. 1977 Aug 15;114(3):433-40 PMID: 909093
Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose--ethidium bromide electrophoresis.
Biochemistry. 1973 Jul 31;12(16):3055-63 PMID: 4354250
Summary of the genetic mapping of prophage Mu.
Virology. 1973 Jul;54(1):90-2 PMID: 4576751
Analysis of bacteriophage mu and lambda-mu hybrid DNAs by specific endonucleases.
J Mol Biol. 1975 Mar 15;92(4):529-40 PMID: 1097703
The DNA modification function of temperate phage Mu-1.
Virology. 1976 Mar;70(1):17-27 PMID: 1258376

Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.136.1.423-428.1978

Published

1978-10-00

Pages

423-8

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC218675

Subset

External Links

PubMed source DOI: 10.1128/jb.136.1.423-428.1978 PMC Full Text View journal details

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