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题目:: Mononuclear cell subsets in patients with oral cancer.
作者:: Eskinazi(D P),Perna(J J),Mihail(R)
状态:: 发布时间1987-08-14 , 更新时间 2015-11-19
期刊:: Cancer
摘要:: Peripheral mononuclear cells of ten patients with oral squamous cell carcinoma (SCC) and ten controls were evaluated for their cell subset composition. Flow cytometry experiments using commercially available subset-specific monoclonal antibodies (of the Leu series) were conducted to determine the percentage and fluorescent pattern of cell subsets. Leu-1+ (total T-cells), Leu-2a+ (T suppressor/cytotoxic cells), Leu-3a+ (T-helper/suppressor-inducer cells), Leu-7+ (natural killer cells), Leu-12+ (B-cells), and Leu-M3+ (monocytes) were analyzed. No significant difference was found between patients and controls in most instances; however, Leu-7+ cells were increased in patients (P less than 0.01). Preliminary experiments (and published evidence) suggest that this increase in Leu-7+ cells reflects an increase in natural killer cells, induced by a soluble factor released by squamous cell carcinoma cells.
语言:: eng
DOI:

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