Plasma-membrane lipid composition and ethanol tolerance in Saccharomyces cerevisiae.

Archives of microbiology ·Vol. 117 ·No. 3 ·1978-06-26 ·Pages 239-45

Thomas DS, Hossack JA, Rose AH

Abstract

Populations of cells suspended anaerobically in buffered (pH 4.5) M ethanol remained viable to a greater extent when their plasma membranes were enriched in linoleyl rather than oleyl residues irrespective of the nature of the sterol enrichment. However, populations with membranes enriched in ergosterol or stigmasterol and linoleyl residues were more resistant to ethanol than populations enriched in campesterol or cholesterol and linoleyl residues. Populations enriched in ergosterol and cetoleic acid lost viability at about the same rate as those enriched in oleyl residues, while populations grown in the presence of this sterol and palmitoleic acid were more resistant to ethanol. Suspending cells in buffered ethanol for up to 24 h did not lower the ethanol concentration.

MeSH Terms

Anaerobiosis Cholesterol/metabolism Drug Resistance, Microbial Ergosterol/metabolism Ethanol/pharmacology Linoleic Acids/metabolism Membrane Lipids/metabolism Oleic Acids/metabolism Saccharomyces cerevisiae/drug effects,metabolism

Chemicals

Linoleic Acids Membrane Lipids Oleic Acids Ethanol Cholesterol Ergosterol

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Thomas D S

Hossack J A

Rose A H

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27 references, click to expand

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Article Info

Journal

Archives of microbiology

Abbr.

Arch Microbiol

ISSN

0302-8933

DOI

10.1007/BF00738541

Published

1978-06-26

Pages

239-45

Language

English

Region

Germany

NLM ID

0410427

Subset

External Links

PubMed source DOI: 10.1007/BF00738541 View journal details

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Plasma-membrane lipid composition and ethanol tolerance in Saccharomyces cerevisiae.

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