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PMID: 3587348 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Prevalence of ras gene mutations in human colorectal cancers.

Nature ·Vol. 327 ·No. 6120 ·1987-00-00 ·Pages 293-7

Bos JL, Fearon ER, Hamilton SR, Verlaan-de Vries M, van Boom JH, van der Eb AJ, Vogelstein B

Abstract

A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.

MeSH Terms

Adenoma/genetics,pathology Carcinoma/genetics,pathology Codon Colonic Neoplasms/genetics,pathology DNA/genetics Humans Mutation Nucleic Acid Hybridization Oncogenes Rectal Neoplasms/genetics,pathology

Chemicals

Codon DNA

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Bos J L

Fearon E R

Hamilton S R

Verlaan-de Vries M

van Boom J H

van der Eb A J

Vogelstein B

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/327293a0

Published

1987-00-00

Pages

293-7

Language

English

Region

England

NLM ID

0410462

Subset

Grants

NCI NIH HHS · CA35494 · United States

NIGMS NIH HHS · GM07309 · United States

External Links

PubMed source DOI: 10.1038/327293a0 View journal details

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Prevalence of ras gene mutations in human colorectal cancers.

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