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PMID: 3586574 Published · ppublish ger Case Reports English Abstract Journal Article

[Recurrent meningitis in familial deficiency of the 8th component of the complement system].

Rezidivierende Meningitis bei familiärem Mangel der achten Komponente des Komplementsystems.

Klinische Wochenschrift ·Vol. 65 ·No. 8 ·1987-04-15 ·Pages 387-90

Keller H, Löke S, Hänsch GM, Jentschura D, Gerhard H, Heene DL

Abstract

An 18-year-old man suffered from recurrent bacterial meningitis. Investigation of the complement system revealed deficiency of the 8th complement component (C8) in the patient and his sister. Genetic defects of the terminal complement components C5 to C8 predispose to Neisseria infections, probably due to a lack in bacteriolytic activity. It is to be noted that 1 year ago the patient had been hospitalized for a culture-proved pneumococcal meningitis.

MeSH Terms
Adolescent Bacterial Infections/genetics,immunology Complement C8/deficiency Humans Male Meningitis/genetics,immunology Recurrence Risk
Chemicals
Complement C8
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Keller H
Löke S
Hänsch G M
Jentschura D
Gerhard H
Heene D L
References (28)
28 references, click to expand
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Article Info
Journal
Klinische Wochenschrift
Abbr.
Klin Wochenschr
ISSN
0023-2173
DOI
10.1007/BF01745581
Published
1987-04-15
Pages
387-90
Language
ger
Region
Germany
NLM ID
2985205R
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01745581
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