Abstract
The present study compares the effects of d-amphetamine (d-AMP) and the potent non-amphetamine CNS stimulant, amfonelic acid (AFA), on the firing rate of single midbrain dopaminergic (DA) neurons and on neostriatal DA metabolism (dihydroxyphenylacetic acid--DOPAC). The results indicate that AFA, like d-AMP, reduces the firing rate of DA neurons, although unlike d-AMP, AFA does not cause a decrease in neostriatal DOPAC content and, in fact, enhances that produced by haloperidol (HALO). The AFA-induced decrease in firing rate, like d-AMP, is reversed by the DA receptor blocker HALO, but again unlike d-AMP, the decrease in firing rate is not prevented by catecholamine synthesis inhibition with alpha-methyl-para-tyrosine. Thus, both amphetamine and amfonelic acid have identical electrophysiological effects on DA neurons but act by different mechanisms.
MeSH Terms
3,4-Dihydroxyphenylacetic Acid/metabolism
Action Potentials/drug effects
Animals
Corpus Striatum/metabolism
Dextroamphetamine/pharmacology
Dopamine/metabolism
Dose-Response Relationship, Drug
Female
Haloperidol/pharmacology
Male
Mesencephalon/drug effects
Naphthyridines/pharmacology
Neurons/drug effects,physiology
Rats
Tyrosine 3-Monooxygenase/antagonists & inhibitors
Chemicals
Naphthyridines
3,4-Dihydroxyphenylacetic Acid
Tyrosine 3-Monooxygenase
Haloperidol
Dextroamphetamine
Dopamine
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
German D C
Harden H
Sanghera M K
Mann D
Kiser R S
Miller H H
Shore P A
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