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PMID: 3552995 Published · ppublish English Journal Article

Passive immunization with antibodies against iron-regulated outer membrane proteins protects turkeys from Escherichia coli septicemia.

Infection and immunity ·Vol. 55 ·No. 5 ·1987-05-00 ·Pages 1239-42

Bolin CA, Jensen AE

Abstract

Escherichia coli septicemia is a common disease of young poultry and several species of mammals. Rabbit antiserum was prepared against iron-regulated outer membrane proteins of E. coli. Eighteen-day-old turkeys were passively immunized with antiserum and challenged by air sac inoculation of 1 X 10(6) to 2 X 10(6) CFU of E. coli O78:K80:H9. Turkeys injected with normal rabbit serum or saline solution before challenge served as controls. Fatalities (8 of 51 turkeys inoculated) occurred only in groups given saline solution or normal rabbit serum. The remaining turkeys were necropsied 96 h after challenge. Passive immunization with antiserum significantly (P less than 0.05) reduced the frequency of bacteremia at 96 h after challenge, the frequency of recovery of E. coli from air sacs, and the severity of gross lesions in inoculated birds as compared with birds given normal rabbit serum or saline solution.

MeSH Terms
Animals Antibodies, Bacterial/administration & dosage Bacterial Outer Membrane Proteins/immunology,metabolism Escherichia coli/immunology,metabolism Escherichia coli Infections/prevention & control,veterinary Immunization, Passive Iron/metabolism Poultry Diseases/prevention & control Sepsis/prevention & control,veterinary Turkeys
Chemicals
Antibodies, Bacterial Bacterial Outer Membrane Proteins Iron
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bolin C A
Jensen A E
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19 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.55.5.1239-1242.1987
Published
1987-05-00
Pages
1239-42
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC260496
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.55.5.1239-1242.1987 PMC Full Text View journal details
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