Direct blockade of antigen-reactive B lymphocytes by immune complexes. An 'off' signal for precursors of IgM-producing cells provided by the linkage of antigen-and Fc-receptors.

Immunology ·Vol. 35 ·No. 1 ·1978-07-00 ·Pages 151-7

Oberbarnscheidt J, Kölsch E

Abstract

Antigen-antibody complexes efficiently inhibit the induction of antibody formation. Using Mishell-Dutton cultures, it can be demonstrated that neither T cells nor their products are required for this inhibition of IgM PFC formation. The blockade is at the level of B cells and cannot be overcome by LPS or TRF. The data demonstrate that cross-linking of antigen- and Fc-receptors by antigen-antibody complexes is a blocking signal for B cells.

MeSH Terms

Animals Antibody Formation Antibody-Producing Cells/immunology Antigen-Antibody Complex B-Lymphocytes/immunology Binding Sites Female Hemolytic Plaque Technique Immunoglobulin Fc Fragments Immunoglobulin M/biosynthesis Immunosuppression Therapy Male Mice Time Factors

Chemicals

Antigen-Antibody Complex Immunoglobulin Fc Fragments Immunoglobulin M

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Oberbarnscheidt J

Kölsch E

References (25)

25 references, click to expand

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Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1978-07-00

Pages

151-7

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1457236

Subset

External Links

PubMed source PMC Full Text View journal details

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Direct blockade of antigen-reactive B lymphocytes by immune complexes. An 'off' signal for precursors of IgM-producing cells provided by the linkage of antigen-and Fc-receptors.

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