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PMID: 3543054 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Hyperglucagonemia and insulin-mediated glucose metabolism.

The Journal of clinical investigation ·Vol. 79 ·No. 2 ·1987-02-00 ·Pages 547-56

Del Prato S, Castellino P, Simonson DC, DeFronzo RA

Abstract

The effect of chronic physiologic hyperglucagonemia on basal and insulin-mediated glucose metabolism was evaluated in normal subjects, using the euglycemic insulin clamp technique (+50, +100, and +500 microU/ml). After glucagon infusion fasting glucose increased from 76 +/- 4 to 93 +/- 2 mg/dl and hepatic glucose production (HGP) rose from 1.96 +/- 0.08 to 2.25 +/- 0.08 mg/kg X min (P less than 0.001). Basal glucose oxidation after glucagon increased (P less than 0.05) and correlated inversely with decreased free fatty acid concentrations (r = -0.94; P less than 0.01) and decreased lipid oxidation (r = -0.75; P less than 0.01). Suppression of HGP and stimulation of total glucose disposal were impaired at each insulin step after glucagon (P less than 0.05-0.01). The reduction in insulin-mediated glucose uptake was entirely due to diminished non-oxidative glucose utilization. Glucagon infusion also caused a decrease in basal lipid oxidation and an enhanced ability of insulin to inhibit lipid oxidation and augment lipid synthesis. These results suggest that hyperglucagonemia may contribute to the disturbances in glucose and lipid metabolism in some diabetic patients.

MeSH Terms
Adolescent Adult Blood Glucose/metabolism Fasting Fatty Acids, Nonesterified/blood Female Glucagon/blood,pharmacology Glucose/metabolism Humans Insulin/blood,pharmacology Kinetics Liver/metabolism Male
Chemicals
Blood Glucose Fatty Acids, Nonesterified Insulin Glucagon Glucose
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Del Prato S
Castellino P
Simonson D C
DeFronzo R A
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI112846
Published
1987-02-00
Pages
547-56
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC424124
Subset
IM
Grants
NIA NIH HHS · AG-00233 · United States
NIADDK NIH HHS · AM-24092 · United States
NCRR NIH HHS · RR125 · United States
External Links
PubMed source DOI: 10.1172/JCI112846 PMC Full Text View journal details
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