Immunohistochemical detection of the terminal C5b-9 complement complex in children with glomerular diseases.

Clinical and experimental immunology ·Vol. 65 ·No. 1 ·1986-07-00 ·Pages 66-72

Rus HG, Niculescu F, Nanulescu M, Cristea A, Florescu P

Abstract

Kidney biopsies were obtained in 28 children with glomerular diseases and studied using indirect immunofluorescence and immunoperoxidase for IgG, IgA, IgM, C1q, C3c, C4, fibrinogen and the neoantigens of the terminal C5b-9 complement complex. C5b-9 deposits were detected in glomeruli of 14, in tubules of eight and in vessels of 12 cases. Patients with C5b-9 deposits fared worse than those without such deposits, even with the same histopathological type of glomerulonephritis. The C5b-9 complex suggests an in situ complement activation.

MeSH Terms

Adolescent Antibody Specificity Child Child, Preschool Complement Activation Complement Membrane Attack Complex Complement System Proteins/analysis Female Fluorescent Antibody Technique Glomerulonephritis/immunology Glomerulosclerosis, Focal Segmental/immunology Humans Immunoenzyme Techniques Kidney Glomerulus/immunology Kidney Tubules/immunology Male Nephrosis, Lipoid/immunology

Chemicals

Complement Membrane Attack Complex Complement System Proteins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Rus H G

Niculescu F

Nanulescu M

Cristea A

Florescu P

References (13)

13 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1986-07-00

Pages

66-72

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1542277

Subset

External Links

PubMed source PMC Full Text View journal details

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Immunohistochemical detection of the terminal C5b-9 complement complex in children with glomerular diseases.

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