Abstract
In order to analyze the initial steps involved in the formation of subepithelial electron-dense immune deposits, the authors induced passive Heymann's nephritis in rats by intravenous injection of monoclonal or polyclonal antibodies to the relevant antigen, a 330,000-dalton brush border protein also expressed within coated pits of glomerular epithelial cells. Whereas both mono- and polyclonal antibodies induced deposits detectable by indirect immunofluorescence, electron-dense deposits were only found in glomerular capillary walls of rats injected with polyclonal antibodies. Immunoultrastructural analysis confirmed the subepithelial location of heterologous IgG: monoclonal antibodies were essentially confined to the coated pits of glomerular epithelial cells, whereas polyclonal antibodies were detected in coated pits and in the subepithelial electron-dense deposits. In the face of an excess of circulating antibody, gp 330 was not detectable in the deposits, but a striking increase in the number of endoplasmic reticula positive for gp 330 was found. The results indicate that highly cross-linked immune complexes formed by polyvalent antibodies on the epithelial cell surface are necessary for the induction of subepithelial electron-dense deposits.
MeSH Terms
Animals
Antigen-Antibody Reactions
Fluorescent Antibody Technique
Immunoglobulins/metabolism
Kidney Glomerulus/metabolism,ultrastructure
Microvilli/metabolism,ultrastructure
Molecular Weight
Nephritis/immunology,metabolism,pathology
Proteins/metabolism
Rats
Chemicals
Immunoglobulins
Proteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Allegri L
Brianti E
Chatelet F
Manara G C
Ronco P
Verroust P
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13 references, click to expand
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