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PMID: 352939 Published · ppublish English Journal Article

Protection against ascending Escherichia coli pyelonephritis in rats and significance of local immunity.

Infection and immunity ·Vol. 20 ·No. 1 ·1978-04-00 ·Pages 78-81

Kaijser B, Larsson P, Olling S

Abstract

Acute pyelonephritis in rats caused by Escherichia coli O6K13H1 produced serum and urinary antibodies against O6 and K13 antigens. This was also seen after intravesical immunization with Formalin-killed bacteria. Both intraperitoneal and intravesical immunization with these Formalin-killed bacteria protected against ascending urinary tract infection induced by homologous bacteria. Passive transfer of urine containing both O6 and K13 antibodies also protected against infection. By absorption experiments it was shown that K13 antibodies were especially important.

MeSH Terms
Animals Antibodies, Bacterial/biosynthesis Antibody Specificity Antigens, Bacterial/administration & dosage Escherichia coli Infections/immunology Female Immunity Immunization Immunization, Passive Pyelonephritis/immunology,prevention & control Rats
Chemicals
Antibodies, Bacterial Antigens, Bacterial
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kaijser B
Larsson P
Olling S
References (16)
16 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.20.1.78-81.1978
Published
1978-04-00
Pages
78-81
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC421554
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.20.1.78-81.1978 PMC Full Text View journal details
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