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PMID: 3523479 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Odorant-binding protein: localization to nasal glands and secretions.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 13 ·1986-07-00 ·Pages 4942-6

Pevsner J, Sklar PB, Snyder SH

Abstract

An odorant-binding protein (OBP) was isolated from bovine olfactory and respiratory mucosa. We have produced polyclonal antisera to this protein and report its immunohistochemical localization to mucus-secreting glands of the olfactory and respiratory mucosa. Although OBP was originally isolated as a pyrazine binding protein, both rat and bovine OBP also bind the odorants [3H]methyldihydrojasmonate and 3,7-dimethyl-octan-1-ol as well as 2-isobutyl-3-[3H]methoxypyrazine. We detect substantial odorant-binding activity attributable to OBP in secreted rat nasal mucus and tears but not in saliva, suggesting a role for OBP in transporting or concentrating odorants.

MeSH Terms
Animals Binding Sites Carrier Proteins/immunology,isolation & purification,metabolism Cattle Chemoreceptor Cells/analysis,metabolism Fatty Alcohols/metabolism Immunosorbent Techniques Molecular Weight Nasal Mucosa/analysis Pyrazines/metabolism Rats Receptors, Odorant Smell/physiology Tears/analysis
Chemicals
Carrier Proteins Fatty Alcohols Pyrazines Receptors, Odorant odorant-binding protein
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Pevsner J
Sklar P B
Snyder S H
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26 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.13.4942
Published
1986-07-00
Pages
4942-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC323860
Subset
IM
Grants
NIDA NIH HHS · DA-00074 · United States
NIGMS NIH HHS · GM-07626 · United States
NIMH NIH HHS · MH-15330 · United States
External Links
PubMed source DOI: 10.1073/pnas.83.13.4942 PMC Full Text View journal details
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