Tissue specificity and developmental expression of rat osteopontin.

Biochemical and biophysical research communications ·Vol. 148 ·No. 3 ·1987-11-13 ·Pages 1129-36

Yoon K, Buenaga R, Rodan GA

Abstract

Osteopontin is a 44 kd phosphoprotein abundant in bone matrix. We isolated a partial length cDNA for rat osteopontin and used it to examine its tissue specificity, its expression during bone development and its hormonal regulation. Osteopontin mRNA is most abundant in bone but is also found in considerable amounts in kidney. Osteopontin mRNA is regulated by the osteotropic hormones dexamethasone and 1,25(OH)2D3. Estimates of osteopontin mRNA levels indicate that the osteopontin gene is turned on relatively late in calvarial development.

MeSH Terms

Age Factors Alkaline Phosphatase/metabolism Animals Bone Development Bone Matrix/metabolism Calcitriol/pharmacology Calcium-Binding Proteins/metabolism Carrier Proteins/metabolism Collagen/metabolism Dexamethasone/pharmacology Gene Expression Regulation/drug effects Kidney/physiology Osteoblasts/metabolism Osteocalcin Osteonectin Osteopontin RNA, Messenger/metabolism Rats Sialoglycoproteins/genetics,metabolism Tissue Distribution

Chemicals

Calcium-Binding Proteins Carrier Proteins Osteonectin RNA, Messenger Sialoglycoproteins Spp1 protein, rat Osteocalcin Osteopontin Dexamethasone Collagen Alkaline Phosphatase Calcitriol

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Yoon K

Department of Bone Biology and Osteoporosis Research, Merck Sharp and Dohme Research Laboratories, West Point, PA 19486.

Buenaga R

Rodan G A

Article Info

Journal

Biochemical and biophysical research communications

Abbr.

Biochem Biophys Res Commun

ISSN

0006-291X

DOI

10.1016/s0006-291x(87)80250-4

Published

1987-11-13

Pages

1129-36

Language

English

Region

United States

NLM ID

0372516

Subset

External Links

PubMed source DOI: 10.1016/s0006-291x(87)80250-4 View journal details

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Tissue specificity and developmental expression of rat osteopontin.

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