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PMID: 3497946 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Induction of class I and class II transplantation antigens in rat brain during fatal and non-fatal measles virus infection.

Journal of neuroimmunology ·Vol. 16 ·No. 2 ·1987-10-00 ·Pages 215-24

Olsson T, Maehlen J, Löve A, Klareskog L, Norrby E, Kristensson K

Abstract

Measles virus induced a marked increase in the expression of MHC-coded class I and class II antigens as detected by immunostaining during both fatal and non-fatal brain infections in rats. The distribution of these molecules in the brain was much more widespread than the occurrence of viral antigen suggesting a soluble factor for their induction. In 14-day-old rats with a non-fatal infection there was a marked infiltration of T lymphocytes of 'cytotoxic/suppressor' phenotype in the brain parenchyma, whereas T 'helper' cell phenotypes mainly were located perivascularly. In brains from newborn rats with a fatal infection no or only few lymphocytes were detected.

MeSH Terms
Animals Antigens, Viral/analysis Brain/immunology HLA Antigens/analysis HLA-D Antigens/analysis Lymphocytes/immunology Major Histocompatibility Complex Measles/immunology,mortality Measles virus/immunology Mice Mice, Inbred BALB C Rats Rats, Inbred Lew
Chemicals
Antigens, Viral HLA Antigens HLA-D Antigens
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Olsson T
Maehlen J
Löve A
Klareskog L
Norrby E
Kristensson K
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34 references, click to expand
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Article Info
Journal
Journal of neuroimmunology
Abbr.
J Neuroimmunol
ISSN
0165-5728
DOI
10.1016/0165-5728(87)90076-2
Published
1987-10-00
Pages
215-24
Language
English
Region
Netherlands
NLM ID
8109498
PMCID
PMC7134084
Subset
IM
External Links
PubMed source DOI: 10.1016/0165-5728(87)90076-2 PMC Full Text View journal details
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