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PMID: 3497873 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

New HLA-A2 variants defined by monoclonal antibodies and cytotoxic T lymphocytes.

Immunogenetics ·Vol. 26 ·No. 3 ·1987-00-00 ·Pages 155-60

Kennedy LJ, Wallace LE, Madrigal JA, Rickinson AB, Bodmer JG

Abstract

Three HLA-A2 variants, A2-DW, A2-KC, and A2-Lee, were identified in three Chinese donors using a panel of monoclonal antibodies. A2-DW was negative with two of the ten HLA-A2 monoclonal antibodies tested, whereas A2-KC was negative with five of the ten and A-2 Lee was negative with one. Epstein-Barr virus-specific cytotoxic T cells generated from the A2-DW donor recognized and killed target cells prepared from the A2-KC donor, but did not recognize target cells from HLA-A2.1, -A2.2, or -A2.4 donors. In isoelectric focusing studies, A2-DW and A2-KC focus in identical positions more acidic than the other HLA-A2 antigens tested.

MeSH Terms
Antibodies, Monoclonal/immunology Cell Line Cytotoxicity, Immunologic Enzyme-Linked Immunosorbent Assay HLA Antigens/immunology Humans Isoelectric Point Polymorphism, Genetic T-Lymphocytes, Cytotoxic/immunology
Chemicals
Antibodies, Monoclonal HLA Antigens
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Kennedy L J
Wallace L E
Madrigal J A
Rickinson A B
Bodmer J G
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28 references, click to expand
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF00365905
Published
1987-00-00
Pages
155-60
Language
English
Region
United States
NLM ID
0420404
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00365905 View journal details
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