Combined familial C7 and C4B deficiency in an adult with meningococcal disease.

Clinical and experimental immunology ·Vol. 67 ·No. 1 ·1987-01-00 ·Pages 55-8

Chapel HM, Peto TE, Luzzi GA, Thompson RA, Fielder AH, Batchelor JR

Abstract

A case of meningococcal septicaemia is reported in an adult with a deficiency of the seventh component of complement combined with a deficiency of the B locus product of C4. A family study demonstrated that the two deficiencies were not linked. This is the first time that the individual alleles of C4 were determined in a patient with a deficiency of one component of the terminal pathway. It is possible that the heterogeneous clinical picture of a terminal pathway deficiency may, in part, be explained by the co-existence of other subtle complement defects.

MeSH Terms

Adult Complement C4/deficiency,genetics Complement C4b Complement C7/deficiency,genetics Humans Male Meningococcal Infections/immunology Pedigree

Chemicals

Complement C4 Complement C7 Complement C4b

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Chapel H M

Peto T E

Luzzi G A

Thompson R A

Fielder A H

Batchelor J R

References (11)

11 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1987-01-00

Pages

55-8

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1542554

Subset

External Links

PubMed source PMC Full Text View journal details

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Combined familial C7 and C4B deficiency in an adult with meningococcal disease.

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