Home LiteratureArticle Details

PMID: 3492909 Published · ppublish English Case Reports Journal Article Research Support, U.S. Gov't, P.H.S.

Thymic hypoplasia associated with isotretinoin embryopathy.

American journal of diseases of children (1960) ·Vol. 141 ·No. 3 ·1987-03-00 ·Pages 263-6

Cohen M, Rubinstein A, Li JK, Nathenson G

Abstract

A newborn had isotretinoin embryopathy, including thymic hypoplasia. Evaluation of her immune functions demonstrated progressive attrition of T cells over the nine weeks until her death due to pneumonia. These studies strongly suggest an insult by isotretinoin to the immune system. Immune abnormalities may predispose infants with isotretinoin embryopathy to infection and contribute to their high mortality.

MeSH Terms

Abnormalities, Drug-Induced/etiology Adult Facial Bones/abnormalities Female Humans Infant, Newborn Isotretinoin Leukocyte Count Maternal-Fetal Exchange Pregnancy Skull/abnormalities T-Lymphocytes Thymus Gland/abnormalities,immunology Tretinoin/adverse effects

Chemicals

Tretinoin Isotretinoin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Cohen M

Rubinstein A

Li J K

Nathenson G

Article Info

Journal

American journal of diseases of children (1960)

Abbr.

Am J Dis Child

ISSN

0002-922X

DOI

10.1001/archpedi.1987.04460030041020

Published

1987-03-00

Pages

263-6

Language

English

Region

United States

NLM ID

0370471

Subset

Grants

NIAID NIH HHS · AI 206-71-03 · United States

External Links

PubMed source DOI: 10.1001/archpedi.1987.04460030041020

Analysis Services

Thymic hypoplasia associated with isotretinoin embryopathy.

Contact

WeChat Official Account