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题目:: Induction of nonspecific cell-mediated cytotoxic reactivity from non-immune spleen cells treated with aloctin A.
作者:: Imanishi(K),Suzuki(I)
状态:: 发布时间1987-01-21 , 更新时间 2006-11-15
期刊:: Int J Immunopharmacol
摘要:: Culturing of mouse spleen cells with aloctin A (Alo A), a lectin having anti-tumor activity, resulted in the induction of cells cytotoxic to syngeneic and allogenic tumor cells in vitro. Alo A-induced killer cells could be generated from spleen cells of natural killer cell-deficient beige mice but not from those of T cell-deficient nude mice. The results of cytotoxicity assay after treatment with antisera plus complement indicated that the killer cells mainly consisted of Thy 1+, Lyt 1-2+, asialo GM1(1)-T cells. Their cytotoxic activity was markedly augmented by the presence of Alo A during the assay for cytotoxicity. The assay of IL2 in the culture fluid from Alo A-treated spleen cells and the effect of dexamethasone (DEX) on IL2 production from Alo A-stimulated spleen cells and on generation of killer cells suggested that generation of Alo A-induced killer cells was closely associated with the amount of IL2 released from the spleen cells in culture.
语言:: eng
DOI:

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