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题目:: A case of human B cell leukemia that implicates an autocrine mechanism in the abnormal growth of Leu 1 B cells.
作者:: Kawamura(N),Muraguchi(A),Hori(A),Horii(Y),Mutsuura(S),Hardy(R R),Kikutani(H),Kishimoto(T)
状态:: 发布时间1986-11-26 , 更新时间 2013-09-29
期刊:: J Clin Invest
摘要:: Production of B cell growth factor (BCGF) from B-chronic lymphocytic leukemia (B-CLL) cells was demonstrated. Freshly isolated monoclonal B-CLL cells expressed surface mu, delta, B1, and Leu 1, but not Ba (an antigen expressed only on activated B cells). Upon stimulation with anti-IgM, they secreted BCGF, which could act on anti-IgM-stimulated autologous leukemic cells as well as anti-IgM-stimulated normal B cells. Cell lines established from these leukemic cells also constitutively secreted BCGF. The BCGF from B-CLL cells or established cell lines induced neither proliferation nor enhanced HLA-DR expression in resting B cells. These results show the presence of B cell-derived BCGF, which is distinct from BSF-1 and effective only on activated B cells. They also suggest that an autocrine mechanism may operate in the growth of B-CLL cells.
语言:: eng
DOI:

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