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PMID: 3489065 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Self-sparing of long-term in vitro-cloned or uncloned cytotoxic T lymphocytes.

The Journal of experimental medicine ·Vol. 164 ·No. 3 ·1986-09-01 ·Pages 962-7

Luciani MF, Brunet JF, Suzan M, Denizot F, Golstein P

Abstract

At least some long-term in vitro-cultured cytotoxic T cell clones and uncloned cell populations are able, in the presence of Con A, to lyse other cells, to be lysed by other cells, but not to lyse themselves. This as-yet-unexplained result may have implications as to the mechanism of T cell-mediated cytotoxicity.

MeSH Terms

Clone Cells Concanavalin A/pharmacology Cytotoxicity, Immunologic Humans Hybridomas T-Lymphocytes, Cytotoxic/immunology

Chemicals

Concanavalin A

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Luciani M F

Brunet J F

Suzan M

Denizot F

Golstein P

References (5)

5 references, click to expand

Studies on the mechanism of lymphocyte-mediated cytolysis. IX. Relationships between antigen recognition and lytic expression in killer T cells.
J Immunol. 1977 Jan;118(1):71-6 PMID: 299763
Characterization of an Lyt-1+ cytolytic T-cell clone specific for a polymorphic domain of the I-Ak molecule.
Scand J Immunol. 1982 Jun;15(6):619-25 PMID: 6181558
Is the T-cell receptor involved in T-cell killing?
Nature. 1986 Feb 27-Mar 5;319(6056):778-80 PMID: 3485254
Cytolytic T cell hybridomas. I. Interleukin 2-independent noncytolytic variants.
Eur J Immunol. 1985 Aug;15(8):751-5 PMID: 3928389
Interactions between MHC-encoded products and cloned T-cells. I. Fine specificity of induction of proliferation and lysis.
Immunogenetics. 1982;16(6):533-49 PMID: 6190737

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.164.3.962

Published

1986-09-01

Pages

962-7

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2188387

Subset

External Links

PubMed source DOI: 10.1084/jem.164.3.962 PMC Full Text View journal details

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Self-sparing of long-term in vitro-cloned or uncloned cytotoxic T lymphocytes.

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