Home LiteratureArticle Details

PMID: 347855 Published · ppublish English Clinical Trial Controlled Clinical Trial Journal Article

Serum lipids and lipoproteins during treatment with oral contraceptives containing natural and synthetic oestrogens. A controlled double-blind investigation.

Acta endocrinologica ·Vol. 87 ·No. 4 ·1978-04-00 ·Pages 855-64

Bostofte E, Hemmingsen L, Møller KJ, Serup J, Weber T

Abstract

暂无摘要

Keywords

Age Factors Biology Contraception Contraceptive Agents Estrogen--side effects Contraceptive Agents Female--administraction and dosage Contraceptive Agents Female--side effects Contraceptive Agents Progestin--administraction and dosage Contraceptive Agents Progestin--side effects Contraceptive Agents--administraction and dosage Contraceptive Agents--side effects Contraceptive Methods--side effects Double-blind Studies Endocrine System Estradiol--administraction and dosage Estradiol--side effects Estriol--administraction and dosage Estriol--side effects Estrogens--side effects Family Planning Hematological Effects Hemic System Hormones Lipid Metabolic Effects Lipids Norethindrone Acetate--administraction and dosage Norethindrone Acetate--side effects Norethindrone--administraction and dosage Norethindrone--side effects Oral Contraceptives Combined Oral Contraceptives--side effects Physiology Research Methodology Studies

MeSH Terms

Adolescent Adult Clinical Trials as Topic Contraceptives, Oral/adverse effects Contraceptives, Oral, Combined/adverse effects Double-Blind Method Estradiol/adverse effects Estradiol Congeners/adverse effects Estriol/adverse effects Estrogens/adverse effects Ethinyl Estradiol/adverse effects Female Humans Lipids/blood Lipoproteins/blood Middle Aged Norethindrone/adverse effects

Chemicals

Contraceptives, Oral Contraceptives, Oral, Combined Estradiol Congeners Estrogens Lipids Lipoproteins Ethinyl Estradiol Estradiol Estriol Norethindrone

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Bostofte E

Hemmingsen L

Møller K J

Serup J

Weber T

Other Abstracts

eng

Increases in serum triglycerides, cholesterol and pre-beta- and beta-lipoproteins have been considered as significant pathogenic factors regarding the possible thrombotic side effect of treatment with oral contraceptives (OCs) of the combined type containing synthetic estrogen. To investigate the influence of natural estrogen (estradiol-17beta + estriolnorethisterone acetate) vs. synthetic oestrogen (ethinyl estradiol-norethisterone acetate) on serum lipids and lipoproteins in young women compared with independent and individual controls, as controlled doubleblind investigation was performed in 33 women in a total material and 18 women in a selected group. The significant changes were: quantitative increases in serum triglycerides (p , .001) and beta-lipoproteins (p , .01) during treatment with synthetic oestrogen

no such change was observed in subjects on natural oestrogen, which was found to decrease serum cholesterol (p , .05), phospholipids (p , .05), and alpha-lipoprotein (p , .05). Quantitative estimation of serum lipoproteins was found to be more valuable than the relative estimation by electrophoresis. It is concluded that OCs containing natural estrogens induce less significant and, qualitatively, more benign changes in serum lipids and lipoproteins than preparations containing a synthetic estrogen do.

Article Info

Journal

Acta endocrinologica

Abbr.

Acta Endocrinol (Copenh)

ISSN

0001-5598

DOI

10.1530/acta.0.0870855

Published

1978-04-00

Pages

855-64

Language

English

Region

Denmark

NLM ID

0370312

Subset

External Links

PubMed source DOI: 10.1530/acta.0.0870855

Analysis Services

Serum lipids and lipoproteins during treatment with oral contraceptives containing natural and synthetic oestrogens. A controlled double-blind investigation.

Contact

WeChat Official Account