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PMID: 3470306 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil.

The Journal of clinical investigation ·Vol. 79 ·No. 4 ·1987-04-00 ·Pages 1110-9

Weintraub MS, Eisenberg S, Breslow JL

Abstract

To study exogenous fat metabolism, we used the vitamin A-fat loading test, which specifically labels intestinally derived lipoproteins with retinyl palmitate (RP). Postprandial RP concentrations were followed in total plasma, and chylomicron (Sf greater than 1,000) and nonchylomicron (Sf less than 1,000) fractions. In normal subjects postprandial lipoproteins were present for more than 14 h, and chylomicron levels correlated inversely with lipoprotein lipase activity and fasting high density lipoprotein (HDL) cholesterol levels and nonchylomicron levels correlated inversely with hepatic triglyceride lipase activity. The main abnormality in type IV patients was a 5.6-fold increase in the chylomicron fraction, whereas in type III patients it was a 6.4-fold increase in nonchylomicrons. Type IIa patients had abnormally low chylomicron fractions. In type IV patients gemfibrozil decreased, whereas in type IIa patients cholestyramine increased the chylomicron fraction 66 and 88%, respectively. This study demonstrates an unexpectedly large magnitude and long duration of postprandial lipemia in normal subjects and patients. These particles are potentially atherogenic, and their role in human atherosclerosis warrants further study.

MeSH Terms
Cholestyramine Resin/therapeutic use Chylomicrons/blood Dietary Fats/administration & dosage Female Gemfibrozil Humans Hyperlipoproteinemia Type II/blood,drug therapy Hyperlipoproteinemia Type III/blood,drug therapy Hyperlipoproteinemia Type IV/blood,drug therapy Lipoproteins/blood Male Pentanoic Acids/therapeutic use Triglycerides/blood Valerates/therapeutic use Vitamin A/administration & dosage
Chemicals
Chylomicrons Dietary Fats Lipoproteins Pentanoic Acids Triglycerides Valerates Cholestyramine Resin Vitamin A Gemfibrozil
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Weintraub M S
Eisenberg S
Breslow J L
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI112926
Published
1987-04-00
Pages
1110-9
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC424291
Subset
IM
Grants
NIA NIH HHS · AG-04727 · United States
NHLBI NIH HHS · HL-32435 · United States
NHLBI NIH HHS · HL-33714 · United States
External Links
PubMed source DOI: 10.1172/JCI112926 PMC Full Text View journal details
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