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PMID: 3458260 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Loss of perforated synapses in the dentate gyrus: morphological substrate of memory deficit in aged rats.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 9 ·1986-05-00 ·Pages 3027-31

Geinisman Y, de Toledo-Morrell L, Morrell F

Abstract

Most, but not all, aged rats exhibit a profound deficit in spatial memory when tested in a radial maze--a task known to depend on the integrity of the hippocampal formation. In this study, animals were divided into three groups based on their spatial memory capacity: young adult rats with good memory, aged rats with impaired memory, and aged rats with good memory. Memory-impaired aged animals showed a loss of perforated axospinous synapses in the dentate gyrus of the hippocampal formation in comparison with either young adults or aged rats with good memory. This finding suggests that the loss of perforated axospinous synapses in the hippocampal formation underlies the age-related deficit in spatial memory.

MeSH Terms
Aging Animals Hippocampus/ultrastructure Memory Memory Disorders/pathology Rats Synapses/pathology,physiology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Geinisman Y
de Toledo-Morrell L
Morrell F
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27 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.9.3027
Published
1986-05-00
Pages
3027-31
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC323440
Subset
IM
Grants
NIA NIH HHS · AG 03410 · United States
External Links
PubMed source DOI: 10.1073/pnas.83.9.3027 PMC Full Text View journal details
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