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PMID: 3457021 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro.

The Journal of clinical investigation ·Vol. 77 ·No. 4 ·1986-04-00 ·Pages 1405-8

Slater LM, Sweet P, Stupecky M, Gupta S

Abstract

The development of drug resistance by tumor cells is a major obstacle to the cure of human malignancy. Cyclosporin A (CsA) completely reverses primary resistance to vincristine and cross resistance to daunorubicin in a pleiotropic drug-resistant subline of human T cell acute lymphatic leukemia. This subline is over 50-fold resistant to vincristine and fivefold resistant to daunorubicin. CsA has little effect on vincristine or daunorubicin activity in drug-sensitive parental leukemia and corrects daunorubicin resistance without altering cellular daunorubicin accumulation.

MeSH Terms
Cell Line Cyclosporins/therapeutic use Daunorubicin/therapeutic use Drug Resistance Drug Synergism In Vitro Techniques Leukemia, Lymphoid/drug therapy Vincristine/therapeutic use
Chemicals
Cyclosporins Vincristine Daunorubicin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Slater L M
Sweet P
Stupecky M
Gupta S
References (15)
15 references, click to expand
  1. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.
    Cancer Res. 1981 May;41(5):1967-72 PMID: 7214365
  2. Verapamil potentiation of VP-16-213 in acute lymphatic leukemia and reversal of pleiotropic drug resistance.
    Cancer Chemother Pharmacol. 1986;16(1):50-4 PMID: 3455667
  3. Verapamil restoration of daunorubicin responsiveness in daunorubicin-resistant Ehrlich ascites carcinoma.
    J Clin Invest. 1982 Nov;70(5):1131-4 PMID: 6182160
  4. Enhancement of vincristine- and adriamycin-induced cytotoxicity by verapamil in P388 leukemia and its sublines resistant to vincristine and adriamycin.
    Biochem Pharmacol. 1982 Oct 1;31(19):3138-40 PMID: 7150340
  5. Increased content of calmodulin in human leukemia cells.
    Leuk Res. 1983;7(1):97-100 PMID: 6834884
  6. Binding of cyclosporine by human lymphocytes and phospholipid vesicles.
    J Immunol. 1983 Aug;131(2):712-8 PMID: 6863928
  7. Vinca alkaloid-resistant phenotype in cultured human leukemic lymphoblasts.
    Cancer Treat Rep. 1983 Oct;67(10):875-82 PMID: 6354435
  8. Calcium modifies the accumulation and retention of daunorubicin by Ehrlich ascites carcinoma.
    Cancer Chemother Pharmacol. 1984;13(1):69-70 PMID: 6733845
  9. Distribution and concentration of cyclosporin in human blood.
    J Clin Pathol. 1984 Oct;37(10):1167-71 PMID: 6386891
  10. Targeted blood levels of cyclosporin for cardiac transplantation.
    J Thorac Cardiovasc Surg. 1984 Dec;88(6):952-7 PMID: 6389991
  11. Anthracycline resistance in P388 murine leukemia and its circumvention by calcium antagonists.
    Cancer Res. 1985 Apr;45(4):1687-91 PMID: 3919944
  12. Cyclosporin A binding to calmodulin: a possible site of action on T lymphocytes.
    Science. 1985 Apr 19;228(4697):337-9 PMID: 3885394
  13. Treatment of acute graft-versus-host disease after allogeneic marrow transplantation. Randomized study comparing corticosteroids and cyclosporine.
    Am J Med. 1985 Jun;78(6 Pt 1):978-83 PMID: 3893112
  14. Promotion of daunorubicin uptake and toxicity by the calcium antagonist tiapamil and its analogs.
    Cancer Treat Rep. 1985 Jun;69(6):673-6 PMID: 4016770
  15. Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.
    Cancer Res. 1982 Nov;42(11):4730-3 PMID: 7127307
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI112450
Published
1986-04-00
Pages
1405-8
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC424510
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI112450 PMC Full Text View journal details
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