Home LiteratureArticle Details
PMID: 344222 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Immunity to experimental renal candidiasis in rats.

Infection and immunity ·Vol. 19 ·No. 2 ·1978-02-00 ·Pages 737-40

Rogers TJ, Balish E

Abstract

Germfree rats were found to be more susceptible to intravenous challenge with Candida albicans than were conventional rats. The resistance of conventional rats could be overcome by increasing the challenge dose. The resistance of the germfree rat was enhanced by vaccination with Formalin-killed C. albicans in complete Freund adjuvant, complete Freund adjuvant, or incomplete Freund adjuvant. These results, and histological evidence obtained from infected gnotobiotic rats, provided further information on the mechanism of resistance to the disseminated form of candidiasis.

MeSH Terms
Animals Candida albicans/immunology Candidiasis/immunology,pathology Disease Models, Animal Freund's Adjuvant Fungal Vaccines Germ-Free Life Immunity Kidney/pathology Kidney Diseases/immunology,pathology Rats
Chemicals
Fungal Vaccines Freund's Adjuvant
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rogers T J
Balish E
References (17)
17 references, click to expand
  1. Experimental Candida albicans infection in conventional mice and germfree rats.
    Infect Immun. 1976 Jul;14(1):33-8 PMID: 780278
  2. Mechanisms involved in elimination of organisms from experimental cutaneous Candida albicans infections in guinea pigs.
    J Immunol. 1976 Aug;117(2):523-30 PMID: 781132
  3. The role of activated macrophages in resistance to experimental renal candidiasis.
    J Reticuloendothel Soc. 1977 Oct;22(4):309-18 PMID: 926088
  4. The role of thymus-dependent cell-mediated immunity in resistance to experimental disseminated candidiasis.
    J Reticuloendothel Soc. 1976 Oct;20(4):291-8 PMID: 994127
  5. Immunity to Candida albicans induced by Listeria monocytogenes.
    Infect Immun. 1974 Jul;10(1):72-82 PMID: 4210334
  6. Immunological features in a case of chronic granulomatous candidiasis and its treatment with transfer factor.
    Clin Exp Immunol. 1972 Jun;11(2):151-63 PMID: 4557179
  7. Chronic mucocutaneous candidiasis: model-building in cellular immunity.
    Ann Intern Med. 1971 Jun;74(6):955-78 PMID: 4931743
  8. An immune factor in baboon anti-candida serum.
    Sabouraudia. 1970 May;8(1):41-7 PMID: 4987707
  9. The enhancing effect of the microbial flora on macrophage function and the immune response. A study in germfree mice.
    J Exp Med. 1966 Jun 1;123(6):1013-24 PMID: 5328828
  10. Chronic mucocutaneous moniliasis with impaired delayed hypersensitivity.
    Clin Exp Immunol. 1970 Mar;6(3):375-85 PMID: 5442521
  11. Passive immunization of mice against Candida albicans.
    Sabouraudia. 1968 Feb;6(2):103-5 PMID: 5647141
  12. Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection.
    J Clin Invest. 1969 Aug;48(8):1478-88 PMID: 5796360
  13. Lymphocytopoiesis, plasmacytopoiesis and cellular proliferation in nonantigenically stimulated germfree mice.
    J Immunol. 1966 Aug;97(2):267-74 PMID: 5921313
  14. ACQUIRED IMMUNITY TO CANDIDIASIS IN MICE.
    J Bacteriol. 1963 Sep;86:401-6 PMID: 14066415
  15. THE RESPONSE OF THE LYMPHATIC TISSUE TO BACTERIAL ANTIGEN. STUDIES IN GERMFREE MICE.
    Am J Pathol. 1964 May;44:747-61 PMID: 14155023
  16. Measurement of candidacidal activity of specific leukocyte types in mixed cell populations I. Normal, myeloperoxidase-deficient, and chronic granulomatous disease neutrophils.
    Infect Immun. 1970 Jul;2(1):42-7 PMID: 16557797
  17. Responses of the Peyer's Patches in Germ-Free Mice to Antigenic Stimulation.
    Infect Immun. 1970 Jul;2(1):96-100 PMID: 16557807
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.19.2.737-740.1978
Published
1978-02-00
Pages
737-40
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC414141
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.19.2.737-740.1978 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2