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PMID: 342913 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A gene involved in the metabolic control of ppGpp synthesis.

Molecular & general genetics : MGG ·Vol. 158 ·No. 3 ·1978-01-17 ·Pages 271-7

Pao CC, Gallant J

Abstract

A genetic locus has been identified which controls the basal synthesis of ppGpp in growing E. coli. Cells carrying a recessive allele of the relX gene have a very low concentration of ppGpp during balanced growth, and fail to accumulate ppGpp in response to carbon/energy source downshift. Moreover, the recessive relX allele renders the cells unable to grow at 42 degrees C and, when coupled with relA, makes the cells sensitive to the presence of leucine in minimal medium. RelX is cotransduced with fuc and relA and located at approximately 59.4 min on the E. coli genetic map.

MeSH Terms
Escherichia coli/genetics,metabolism Genes, Regulator Guanine Nucleotides/genetics Guanosine Tetraphosphate/biosynthesis,genetics Phenotype RNA, Bacterial/biosynthesis,genetics
Chemicals
Guanine Nucleotides RNA, Bacterial Guanosine Tetraphosphate
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pao C C
Gallant J
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30 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00267198
Published
1978-01-17
Pages
271-7
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00267198
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