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PMID: 3426290 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Xanthine oxidoreductase is present in human synovium.

Annals of the rheumatic diseases ·Vol. 46 ·No. 11 ·1987-11-00 ·Pages 843-5

Allen RE, Outhwaite JM, Morris CJ, Blake DR

Abstract

It is postulated that the mobile inflamed joint may be subject to cyclical ischaemic reperfusion injury. Xanthine oxidoreductase is an enzyme thought to contribute to oxidative reperfusion injury, and the detection of this activity in human synovium is described. Three normal and five rheumatoid tissues were assayed with a carbon-14 radioassay detecting the conversion of [14C]xanthine to [14C]uric acid. Rheumatoid synovia contained 0.67-305 microU/g tissue (n = 5), while normal synovia contained 1.2-5.0 microU/g tissue (n = 3).

MeSH Terms
Allopurinol/metabolism Arthritis, Rheumatoid/enzymology Humans NAD/metabolism Synovial Membrane/enzymology Xanthine Oxidase/metabolism
Chemicals
NAD Allopurinol Xanthine Oxidase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Allen R E
Rheumatism Research Wing, Medical School, Birmingham.
Outhwaite J M
Morris C J
Blake D R
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20 references, click to expand
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Article Info
Journal
Annals of the rheumatic diseases
Abbr.
Ann Rheum Dis
ISSN
0003-4967
DOI
10.1136/ard.46.11.843
Published
1987-11-00
Pages
843-5
Language
English
Region
England
NLM ID
0372355
PMCID
PMC1003403
Subset
IM
External Links
PubMed source DOI: 10.1136/ard.46.11.843 PMC Full Text View journal details
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