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题目:: Expressed recombinant cadherins mediate cell sorting in model systems.
作者:: Nose(A),Nagafuchi(A),Takeichi(M)
状态:: 发布时间1988-10-25 , 更新时间 2006-11-15
期刊:: Cell
摘要:: Cadherins are cell-surface glycoproteins responsible for Ca2+-dependent cell-to-cell adhesion. E- or P-cadherin was transfected into L cells, which normally have little cadherin activity, and cellular aggregation of the resulting transfectants was observed to be a function of the cadherin molecule expressed. Transfected cells preferentially adhered to cells expressing the same cadherin subclass. Furthermore, in reconstituted embryonic lung tissue, E-cadherin-expressing L cells were associated with epithelial tubules expressing E-cadherin, while untransfected L cells associated with mesenchymal cells. These results provide the first direct evidence that the differential expression of cadherins can play a role in cell sorting in heterogeneous cell populations.
语言:: eng
DOI:

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